I was turned on to Choline many years ago, has always helped me with relaxation and concentration. My husband more recently started taking pramiracetam, Pramiracetam Bulk Powder 25 Grams to help him focus on a big project for work. Turns out when you combine it with choline the effects are increased significantly. I've been more alert and "switched on" during the day, and able to relax more easily I think, in social situations. A good one two punch!
I've always been a fan of source naturals. Their choline/inositol comes across as high quality, and does what it's intended to do. Most people don't get enough choline in their diet; this is a good way to fix that.
Instead of taking one large pill, I tend to split them in two...half in the morning, half at night. But whatever works for you.
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Both my mate and I suffer from anxiety. For years we
squabbled when one or both of us felt uptight. By using inositol/choline we are getting along better and sleeping better.
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The quality is fine, as far as I can tell, but the form factor is atrocious. I don't have any trouble swallowing pills, and usually don't even bother to use water, but these are an unpleasant challenge. They're very large and have a rough dry surface. It takes a lot of effort to swallow them, and even washing them down with water, they *always* get stuck in my throat. I'm going to look for a brand that comes in capsules, even if they have a smaller dose. I'd rather take two or three capsules than one of these horse pills.
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Source Naturals Inositol/Choline is a nice find because it combines two common agents used in cognitive enhancement. The drawback is that the form of choline used (i.e., choline bitartrate) does not have the highest bioavailability. In other words, it doesn't absorb well under normal conditions. The way around this is choline alfoscerate, or Alpha-GPC a similar precursor to acetycholine with higher bioavailability and the ability to cross the blood-brain barrier. It is significantly more expensive, but it works (and studies are available evidencing its benefits). If the price is too high, you can increase your intake of choline bitartrate, but I wouldn't do it with a combination supplement and I would definitely research the tolerance levels of doing such (choline bitartrate is relatively safe at normal doses, but I'm not a physician).
Also, do not expect to have dramatic improvements in cognition with just choline bitartrate and inositiol you will be disappointed. A real effort at doing such takes a battery of substances to accomplish, first and foremost would be a quality vitamin and mineral supplement with adequate daily water intake. Second, some form of physical activity on a routine basis (yes, exercise). Third, a diet that is a diet in other words, do not reduce your food consumption, alter your food consumption to healthier habits (in fact, a caloric increase might be necessary with cognitive enhancement).
But take note that many nootropics (cognitive enhancers) work synergistically; namely, they require the presence of other substances to actually work choline and inositol are synergistic, but other substances can be of great aid too. Aniracetum is a great choice to combine with these two mentioned, still, others can be added too; for example: phenylethylamine HCL, phosphatidyl-serine, acetyl-l-carnitine, acetyl-l-tyrosine, alpha lipoic acid, DHA, Ginseng, Ginkgo Biloba, dopa mucuna, etc. Cognitive enhancement regiments can deplete levels of standard minerals in the body this is one reason why a decent vitamin and mineral supplement is so important. Some of the listed nootropics can react negatively with antidepressants particularly those like MAOIs and to some extent SSRIs, SNRIs, &/or NRIs if you take any medication of this sort, consult a physician before you begin putting these substances into your body. In fact, even if you do not take those particular medications, a physician will be willing to listen and advise you according to your specific goals and your specific needs, even if it is cognitive enhancement.
As for the size of the pill in question, I have been supplementing for some time now with the aim at cognitive enhancement the size of this pill is not outside of the norm. Even basic calcium supplements are usually the same size, if not bigger. If you feel like this is a giant pill, take a look at a 1000mg supplement of l-Lysine hydrochloride & report back it has different benefits, but if you can acclimate yourself to taking that, these will go down absolutely without discomfort. But, if it truly is that difficult for you to get the pill down, you could try a pill splitter, but you will be left with rough edges on the pill discomfort could turn to irritation or pain; or you could grind it down with a mortar and pestle and mix it with food, but there is taste factor that will make it difficult to get down too. I've tried the powdered route mixed with shakes even with piracetam (extremely bitter) and it works, but you have to take the shake down in one effort, no sipping you will likely engage your gag reflex depending on how dilute you make the mixture. Simply put, the pill as manufactured is designed to go down with the least amount of discomfort. A last resort, if you simply cannot get the pill down, then just buy the two supplements independently don't force yourself on pressure of others to something that could result in harm to yourself.
For Source Natural's product, I like the combination it is sufficient in my regiment and saves me money; however, it appears many reviewers are dealing with serious illnesses I would study carefully what you can get from this and other supplements; many can help, but many can also have other unknown and/or unconsidered side-effects. I would personally get a physician's opinion, especially if you begin a regiment of supplements or if you want to alter the recommended dosages they will listen to your concerns; if they do not, then they are not true professionals and a reevaluation of which physician you see may be in order. Never be afraid to ask your doctor about taking any substance into your body show them what you've seen on the internet, the studies you've read and make it known what your intentions are; they will not judge you or ridicule you they will help and guide you in confidence.
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I have been weight lifting since 8th grade and started getting serious and using supplents since my senior year of high school, I am now a freshmen in college. I am very into lifting, my bench max is 320 my squat max is 450 and my deadlift max is around 560. I would definetly recomend powerfull, I used it with jack3d during my GVT (german volume training) and 5/3/1 and it helps me out tremendously. I have used 3 cycles of Powerfull and cant begin to express my love ffor it. The sleep is fantastic and it speeds up recovery, I will say that dreams are a little weird, maybe thats just me. I would recommend this product to any serious lifter or body builder or athelte. USP LABS IS THE BOMB!
